New Technologies 2: Thanks to 3D Biomass Technology, Lifelike Blood Vessels are created

Lifelike Blood Vessels are created

Scientifically it is a very difficult process to reproduce lifelike blood vessels from scratch. Because blood vessels cary the main foods into veins and throw away toxic waste from the body.

A team from Brigham and Women’s Hospital's team made progress in the production of blood vessels using a 3D bioprinting technique. The study was published online in Lab On a Chip in May.

'Scientists have taken incredible steps to produce complex artificial tissues such as heart, liver and lung. ’ 

[caption id="attachment_176828" align="alignnone" width="700"] lifelike blood vessels[/caption]

Khademhosseini said;

‘However, producing artificial blood vessels still remains a critical task for tissue engineering. In order to accomplish this task, we propose a unique strategy for the transformation of hydrogel units into vessels by combining the developments in 3D biomass technology with biomaterials. ’

The researchers used a 3-D biostrinter to make an agarose (sugar-based molecule derived from nature) spindle template, primarily as a template for blood vessels.  After that, they  coated this gelatin-like material with a hydrogel called and reinforced with photo-crosslinking.

‘Our approach involves writing agarose fibers with bioprinting technology that turn into blood vessel channels. What makes our approach unique is that the fiber patterns we write are strong enough to open channels when physically removed.' said Khademhosseini.

[caption id="attachment_176830" align="alignnone" width="1080"] lifelike blood vessels[/caption]

In this way, the melting of these mold layers can be prevented from escaping the cells they enclose. Khademhosseini and his team succeeded in constructing microchannel networks with different architectural features. In addition, they accommodate the majority of frequently used hydrogels and these functional and nutrient microchannels at different concentrations. Such as hydrogels based on methacrylate gelatin or ethylene-glycol.

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